Psoriasis vulgaris is the most common clinical form of psoriasis, which refers to a chronic, relapsing disease of the skin that are manifested in the characteristic of the rash on the body. So-called normal, or plaque psoriasis. According to the most recent statistics, about 2 percent of the world's population suffers from this disease.
The etiology of the disease
In the gym there is enough for a lot of the theories that attempt to explain the cause of your psoriasis. However, none of them is dominant. Many of the professional and leadership tend to be genetic, it can occur in patients of psoriasis. Observe, if you there is a overwhelmed by the a detailed medical history about this skin disease and then the pathology of the debut at a very young age. In the event of failure of the charge to inheritance psoriasis vulgaris begin to manifest themselves in older age.
In addition to this, it must be stressed to a failure in the normal functioning of the immune system. As well as the factors stimulating considering the following:
- Many of the diseases.
- To regulate the emotional with a stressful situation.
- Drugs (- blockers, antimalarial tools, the oral contraceptive, and Dr).
- A reduction in the level of calcium in the blood.
- The abuse of alcohol.
- In adverse weather conditions.
- On the injury.
The clinical
For the disease characterized by periods of exacerbation and remission. Most often, the infection, and a strong mental stress have become the causes of the development of the exacerbation the skin of the disease. Because, in the winter, many of the patients, and basically, it is to be reduced. Clinical semiology in psoriasis:
- The skin is formed of flat papules, which is dramatically enclosed in a surface.
- Psoriatic papules that are pink to rose-red. On top of those that are detected, with loose scales, and white-white cast.
- It occurs in the symptom of "stearic spot". Scratching and rubbing papules, it is better treatments. On the surface, reminiscent of a drop of stearin.
- The norovirus is a symptom of the "terminal film". By removing the scales with the populations, the items in the skin, it stays moist, shining on the surface.
- A particular symptom as "a dew". Continuing the scratching of the surface from the elements, it may be observed small drops of blood on it.
- In any area of the body can be made of the plates.
- The knees, the elbows, the hairy part of the head is preferred to a location in the ordinary form of the disease.
That is, these costs are the responsibility of the when the psoriasis? There is nothing like a bunch of flaky psoriatic papules, covered with the blue-grey of the bark, and they tend to be peripheral to the face. They come in a variety of sizes and shapes. They are found in isolation, such as the large boards, and occupying an extensive area of the body.
The characteristics of the current
Psoriasis vulgaris has a three-phase current, each of which is characterized by the features:
- Moving forward. They appear in small nodules with a shiny-one-touch-of-color-to-pink, with a tendency to peripheral growth. They are trained with typical populations of the plate. We have found the new skin rash at the site of an old eruption, and the area of the injury to, or irritation of the skin, abrasion, scratch, scratches, and Dr).
- Fixed. The emergence of a new rash, is not to be celebrated. Its pathological elements, it becomes more clear. It is missing the buildup of plaque from the inner city.
- Retrogressive. Badge is flat, it decreases the shedding and cell infiltration. The items in the leather settle, forming a pocket of hypo-and hyperpigmentation.
Treatment
As it is used as a common plaque psoriasis? Today, they continue to be the development of new methods for the treatment of this severe skin disease. The fact is that there is no existing treatment method can not give a guaranteed effect. Now, to achieve a permanent cure is not possible. The most that can be hoped for in the modern therapy is to minimize the skin symptoms of the disease.
A selection of historical exchange rates to take into account the form and stage of the disease, the prevalence of anomalies of the eruption, the condition of the patient. Basically, the treatment of psoriasis vulgaris is quite broad, involving a mix of drug for use in the open air, and in the application of the system.
Outside of therapy
The predominant majority of the cases, the extreme caution when psoriasis and to provide the appropriate outdoor therapy. If you experience mild forms of the disease are confined to the local application of the drug. In the progress of the prescribed treatment with the greatest caution, so as not to cause deterioration of the skin symptoms. The more the inflammation, the lower is the concentration of the drug for the external use. Generally, the use of carbohydrate tools, and salicylic drugs, and herbal baths.
When, in the notes to the stationary or retrogressive stage of the disease, the use of different kinds of creams (for example, Naftalan, alarm, salicylic acid), and other methods of treatment. Don't forget that for the duration of the treatment course and the choice of a medicine that uniquely identifies it with your doctor.
According to the standard protocols for clinical trials, the psoriasis vulgaris is treated with the following medications:
- Hydrate and tools.
- The acid is salicylic acid.
- Preparations based on coal tar.
- Naftalan ointment.
- The locations of the retinoids.
- Pyrithione zinc and.
- The derivatives of vitamin D3.
- The corticosteroids.
Hydrate from the toolbar
One of the components is the basis for the treatment of psoriasis vulgaris is moisture on medicinal products for external use only. Carbohydrate the medication they provide:
- A flexible scaly surface area of a psoriatic flare-up.
- The reduction of the shrinkage of the skin.
- To improve your skin.
Especially moisturizers, are presented in lanolin creams that contain vitamin e are useful in the active add-ins. Considering the results of international research, after the application of a hydrating medication in one third of patients and may occur a pronounced positive effect on the reduction of the itch, reduce the redness and peeling.
Salicylic drugs
Typically, the concentration of the salicylic acid in the ointments used for the treatment of psoriasis vulgaris varies from 0.5% to 5%. It can be combined with any of the drugs, with the tar, and corticosteroids. The main pharmacological properties of the acid and salicylic acid:
- The Anti-septic.
- An Anti-inflammatory.
- Keratoplasties (it restores the stratum corneum of the epidermis).
- Keratolytic.
It is well known that in salicylic acid, an ointment helps to strengthen the effect of foreign steroids, so many times in a match. It is characterized by a fast penetration into the skin and into the blood stream. It is for this reason that you do not lubricate the large affected surface area, the concentration of the drug at more than 2 per cent. Express an allergic reaction to the salicylic acid may rarely occur. However, it may increase the inflammatory process in the skin.
Art tools
Generally, the gum, the drugs that are used in the form of an ointment or paste with concentrations of 5% to 15%. Often combined with other medicinal products for external use only. In the post-soviet countries, apply the ointment to the base of the tar. In Europe, the preference is for a carbon mat. Notice that the activity is an order of magnitude greater than that of salicylic acid. We highlight the main effects of the drugs, the tar sands:
- An Anti-inflammatory.
- Keratoplasties.
- Intextricably.
It is, however, quite unpleasant and the smell is limited to your application. In addition to that, they can't be lubed his face. He found that the pitch increases photosensitivity, so it is often combined with ultraviolet light. At the same time, they didn't use it long-term at a high concentration, as it can have an impact on the body, with the development of the lesions in the kidneys, the amount of poisoning, paralysis, and t. d., the treatment of the scalp, use a shampoo that is dermatological with a boy.
Pyrithione zinc
It displays the following pharmacological action:
- Anti-microbial.
- An anti-fungal.
- Antproliferatepnoe. It is involved in the suppression of the pathological growth of the cells of the epidermis.
In addition to this, it helps to reduce the inflammatory process, and reduce leakage and skin rashes. The application of the spray and the cream is recommended for skin disease. When the spread of a disease process in the fibrous part of the head, stumbling, spray, or shampoo. The national and clinical studies have shown that Pirition zinc is also effective in the treatment of psoriasis in 85% of cases. To clear your skin of symptoms of the disease, it's possible through 20 to 25 days of treatment.
This is a typical of the gradual development of a therapeutic effect (a reduction in the itching sensation, thus eliminating the peel, the reduction of the redness). When you do this, you may experience a rapid improvement in the quality of life for people who suffer from psoriasis vulgaris. In the majority of patients, has been held sufficient for a good portability of the product. It is permitted to use in children as young as three years old.
The derivatives of vitamin D3.
Quite some time ago, and as a therapy applies the drug, which belongs to the synthetic analogues of vitamin D3. Apply it on the affected area twice a day. They are committed to the database, that is, the level of efficiency of gluco-KORtikostEroidtion ointment from the first-and second-class, it's pretty much the same thing.
The emergence of the expressed clinical effect of the application of the air based on the vitamin D3 is meant to be celebrated by 95% of the time. However, in order to achieve strong effect, it is necessary to spend a lot of long-lasting course of treatment, which usually lasts from a few months to a year. In some of the patients in these creams may cause the development of skin irritation of the integument, dermatitis, fotocustVItelnostand, to improve the level of calcium in the blood due to the disease. The positive reinforcement of the action to occur when it is coupled with the naming of a derivative of vitamin a, D3, e and phototherapy.
Corticosteroids
Application of topical corticosteroid for the treatment of psoriasis and has been widely used in dermatological practice. Currently, the pharmaceutical industry, the national is filled with different types of withtEroidнымand of creams, gels, and creams. Key benefits:
- An Anti-inflammatory.
- Antihyperglycemic (reduction of pathological growth of the cells of the epidermis).
- Abouttandвonаллергandчеwithкandй.
- A Local pain relievers.
Most experts recommend the initiation of treatment with the most easy-to-steroids-drugs. In the event of an exacerbation, and the lack of therapeutic effect, to spend more and more strong. At the same time, the american academy of dermatology use all the tactics are different. The first use of the drug is strong to get more results faster. And then move on to supportive therapy, and applying it to the weakest glucokoptukoctepoud.
The most common effects and symptoms of the places on our:
- Atrophic changes in the skin.
- Excessive hair growth in areas of application outside of the tools.
- The expansion of the small capillaries of the skin (varicose veins).
- The development of pustular lesions in the skin.
Each of the forms of a glucocorticosteroid drug, it has its own unique characteristics and applications advantages and benefits:
- The medicine is in the form of an ointment does not spread and create a film that's good on the area of application, which helps to eliminate harmful than one the oven.
- Medicines in the form of a cream, and you better deal with the bridges of the inflammation, and moisturize and cool the skin.
- Without the oil, the lotion is also very convenient for the processing on the scalp. Do not take the merge that you have done, and the commitment of its structure.
The system of therapy
With the development of severe forms of psoriasis, involving a system of treatment, which includes the following duties:
- The aromatic retinoid.
- Methotrexate.
- Immunodepressant drugs.
- ГлюкonKORtikostEroids.
The therapeutic course of usual continues for up to two months. That is very effective for the treatment of severe and complicated forms of the disease. The dosage and duration of therapy-such shall be determined, taking into account the severity of the psoriasis.
Physical therapy
When the psoriasis is a widely enough applied to a wide variety of physical therapy treatments. We have listed the most frequently assigned on the techniques of physical therapy treatment:
- Fotonхandмandontерапandя (PUVA).
- The combination of PUVA therapy and.
- Selection of the therapy.
Fotonхandмandontерапandя is the simultaneous use of uv radiation to photo-sensitization of the drug, which is taken to be within about 120 minutes prior to the start of the procedure. Usually fotonхandмandontерапandя held up to four times a week. The course consists of about 20 proceedings. You can combine the PUVA-therapy with retinoid. Contra-indications for carrying it out is considered to be an acute inflammatory condition, and worsening of chronic diseases, the most serious problems in the cardiovascular system, oncology, procedure, diabetes mellitus, and severe disturbances in the functioning of the kidneys and the liver.
In some cases, the use of the selective phototherapy, which is the use of ultra-violet radiation, without the photo-sensitization of drugs of abuse. If there is thick psoriatic plaque, or do not, there are contra-indications for photochemotherapy, and then give you the fotontерапandю.